Amino acids 149 and 294 of human lecithin:cholesterol acyltransferase affect fatty acyl specificity
We identified two regions of human LCAT (hLCAT) that when mutated separately to the corresponding rat sequence (E149A and Y292H/W294F) and transiently expressed in COS-1 cells increased phospholipase A2 (PLA2) activity by 5.5- and 2.8-fold, respectively, and increased cholesteryl ester (CE) formatio...
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| Glavni autori: | , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2004-12-01
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| Serija: | Journal of Lipid Research |
| Teme: | |
| Online pristup: | http://www.sciencedirect.com/science/article/pii/S0022227520341110 |
| Oznake: |
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