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A conserved KL2-capsule-related phage-resistant mechanism in carbapenem-resistant Acinetobacter baumannii is surmountable by a rationally selected dual-phage cocktail

IntroductionAs the use of bacteriophages to combat drug-resistant bacteria increases, phage resistance, which may lead to infection recurrence, has gradually gained attention. The intricate mechanisms underlying phage resistance, which are crucial for improving the efficacy of phage therapy, have no...

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Hlavní autoři: Yong Shao, Zhu Gao, Hongyang You, Shaokun Zhang, Jiaqi Zeng, Jiawei Zhao, Chenyan Yuan, Fengqin Miao, Yuqing Shen, Ying Zhang, Ling Liu, Jianqiong Zhang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2026-04-01
Edice:Frontiers in Cellular and Infection Microbiology
Témata:
Acinetobacter baumannii
bacterial infection
phage resistance
phage therapy
phage cocktail
On-line přístup:https://www.frontiersin.org/articles/10.3389/fcimb.2026.1790430/full
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