CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML

A growing number of human diseases have been found to be associated with aberrant DNA methylation, including cancer. Mutations targeting genes encoding DNA methyltransferase (DNMT), TET family of DNA demethylases, and isocitrate dehydrogenase (IDH1, IDH2) that produce TET inhibitory metabolite, 2-hy...

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Bibliografische Detailangaben

Hauptverfasser:	Peng Liu, Jin-Pin Liu, Si-Jia Sun, Yun Gao, Yingjie Ai, Xiufei Chen, Yiping Sun, Mengyu Zhou, Yun Liu, Yue Xiong, Hai-Xin Yuan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-07-01
Schriftenreihe:	Frontiers in Cell and Developmental Biology
Schlagworte:	DNA methylation CBFB-MYH11 DNMT3A mutually exclusive mutation RUNX1
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fcell.2021.675424/full
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