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Early life infection with Cryptosporidium parvum induces inflammatory responses to dietary antigens

To examine the effect of early-life infection with Cryptosporidium parvum on the development of oral tolerance, we developed a low-dose infection model in neonatal mice. C. parvum infection in neonatal mice results in immunopathology in the colon. IL-1β released during C. parvum infection blocked th...

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Principais autores: Iti Saraav, Wanyi Huang, Jisun Jung, Rui Xu, Yong Fu, Keely McDonald, Lawrence A. Schriefer, Rachel Rodgers, Megan T. Baldridge, Rodney D. Newberry, Chyi-Song Hsieh, L. David Sibley
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2025-12-01
Serier:Gut Microbes
Fag:
Cryptosporidium
enteric infection
regulatory T cells
oral tolerance
dietary antigen
TH1 inflammatory response
Online adgang:https://www.tandfonline.com/doi/10.1080/19490976.2025.2551115
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