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Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6[S]

Cholesterol homeostasis is crucial for cellular function and organismal health. The key regulator for the cholesterol biosynthesis is sterol-regulatory element binding protein (SREBP)-2. The biochemical process and physiological function of SREBP-2 have been well characterized; however, it is not cl...

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Principais autores: Rongya Tao, Xiwen Xiong, Ronald A. DePinho, Chu-Xia Deng, X. Charlie Dong
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2013-10-01
Serier:Journal of Lipid Research
Fag:
gene regulation
transcription
histone acetylation
epigenetics
sirtuin 6
forkhead box O3 transcription factor
Online adgang:http://www.sciencedirect.com/science/article/pii/S0022227520353001
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