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Inhibition of toll-like receptor 4 protects against inflammation-induced mechanobiological alterations to intervertebral disc cells

Intervertebral disc (IVD) degeneration is associated with elevated levels of inflammatory cytokines implicated in disease aetiology and matrix degradation. Toll-like receptor-4 (TLR4) has been shown to participate in the inflammatory responses of the nucleus pulposus (NP) and its levels are upregula...

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Principais autores: TD Jacobsen, PA Hernandez, NO Chahine
Formato: Artigo
Idioma:Inglês
Publicado em: Forum Multimedia Publishing LLC 2021-05-01
coleção:European Cells & Materials
Assuntos:
intervertebral disc
mechanobiology
inflammation
cell mechanics
toll-like receptor-4
actin cytoskeleton
Acesso em linha:https://www.ecmjournal.org/papers/vol041/pdf/v041a37.pdf
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