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The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice

Abstract Background Depression is two-to-three times more frequent among women. The hypothalamus, a sexually dimorphic area, has been implicated in the pathophysiology of depression. Neuroinflammation-induced hypothalamic dysfunction underlies behaviors associated with depression. The lipopolysaccha...

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Principais autores: Fu-Rong Xu, Zhen-Hong Wei, Xiao-Xia Xu, Xiao-Gang Zhang, Chao-Jun Wei, Xiao-Ming Qi, Yong-Hong Li, Xiao-Ling Gao, Yu Wu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-12-01
Serier:Journal of Neuroinflammation
Fag:
Depression
Sex
Neuroinflammation
Hypothalamus
Neurosteroid biosynthesis
Pregnenolone
Online adgang:https://doi.org/10.1186/s12974-023-02976-7
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