NeoPAIR-T: Functional Mapping of Neoantigen–TCR Pairs Using a CRISPR-Engineered Jurkat Reporter System

Targeting mutation-derived neoantigens is a promising strategy for personalized immunotherapies. However, identifying true neoantigens and cognate T cell receptors (TCRs) remains challenging because computational prediction of neoantigen peptides is uncertain and most tumor-infiltrating lymphocytes...

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Hlavní autoři:	Koji Nagaoka, Yukari Kobayashi, Kazuhiro Kakimi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2025-11-01
Edice:	Cells
Témata:	neoantigen T-cell receptor functional screening CRISPR/Cas9 personalized immunotherapy single-cell analysis
On-line přístup:	https://www.mdpi.com/2073-4409/14/22/1789
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