Design, Synthesis, and Cytotoxicity Assessment of [⁶⁴Cu]Cu-NOTA-Terpyridine Platinum Conjugate: A Novel Chemoradiotherapeutic Agent with Flexible Linker

Maximum benefits of chemoradiation therapy with platinum-based compounds are expected if the radiation and the drug are localized simultaneously in cancer cells. To optimize this concomitant effect, we developed the novel chemoradiotherapeutic agent [⁶⁴Cu]Cu-NOTA-C3-TP by conjugating, via...

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Hauptverfasser:	Meysam Khosravifarsani, Samia Ait-Mohand, Benoit Paquette, Léon Sanche, Brigitte Guérin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-08-01
Schriftenreihe:	Nanomaterials
Schlagworte:	copper-64 chemoradiotherapeutic agent cytotoxic activity platinum-based compounds terpyridine platinum low energy electrons
Online-Zugang:	https://www.mdpi.com/2079-4991/11/9/2154
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