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Berberine prevents lethal EV71 neurological infection in newborn mice

Enterovirus 71 (EV71) is the major pathogen causing fatal neurological complications of hand, foot, and mouth disease (HFMD) in young children. Currently no effective antiviral therapy is available. In the present study, we found that natural compound Berberine (BBR) displayed potent inhibitory effe...

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Principais autores: Guangyi Cui, Han Wang, Chongting Yang, Xiaoxiao Zhou, Junyi Wang, Tong Wang, Tonghui Ma
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-10-01
Serier:Frontiers in Pharmacology
Fag:
hand foot and mouth disease
EV71
BBR
neural infection
astrocytes
inflammatory storms
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2022.1027566/full
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