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ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component

Background: Sporadic venous malformation (VM) and angiomatosis of soft tissue (AST) are benign, congenital vascular anomalies affecting venous vasculature. Depending on the size and location of the lesion, symptoms vary from motility disturbances to pain and disfigurement. Due to the high recurrence...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Suvi Jauhiainen, Henna Ilmonen, Pia Vuola, Heta Rasinkangas, Heidi H Pulkkinen, Sara Keränen, Miika Kiema, Jade J Liikkanen, Nihay Laham-Karam, Svetlana Laidinen, Mustafa Beter, Einari Aavik, Kimmo Lappalainen, Jouko Lohi, Johanna Aronniemi, Tiit Örd, Minna U Kaikkonen, Päivi Salminen, Erkki Tukiainen, Seppo Ylä-Herttuala, Johanna P Laakkonen
Hōputu: Artigo
Reo:Inglês
I whakaputaina: eLife Sciences Publications Ltd 2023-05-01
Rangatū:eLife
Ngā marau:
venous malformation
angiomatosis of soft tissue
stromal cells
TGFA
PIK3CA p.H1047R
afatinib
Urunga tuihono:https://elifesciences.org/articles/82543
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