Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response

High-grade serous ovarian cancers (HGS-OvCa) frequently develop chemotherapy resistance. Here, the authors through a systematic analysis of proteomic and drug response data of 14 HGS-OvCa PDXs demonstrate that targeting apoptosis regulators can improve response of these tumors to inhibitors of the P...

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Autors principals:	Ioannis K. Zervantonakis, Claudia Iavarone, Hsing-Yu Chen, Laura M. Selfors, Sangeetha Palakurthi, Joyce F. Liu, Ronny Drapkin, Ursula Matulonis, Joel D. Leverson, Deepak Sampath, Gordon B. Mills, Joan S. Brugge
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2017-08-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-017-00263-7
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