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Effects of N-glycans on the structure of human IgA2

The transition of IgA antibodies into clinical development is crucial because they have the potential to create a new class of therapeutics with superior pathogen neutralization, cancer cell killing, and immunomodulation capacity compared to IgG. However, the biological role of IgA glycans in these...

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Autori principali: Valentina Ruocco, Clemens Grünwald-Gruber, Behzad Rad, Rupert Tscheliessnig, Michal Hammel, Richard Strasser
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2024-04-01
Serie:Frontiers in Molecular Biosciences
Soggetti:
N-linked glycan
IgA antibodies
SAXS
flexibility
protein assembly
protein stability
Accesso online:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1390659/full
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