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The sensitivity of acute myeloid leukemia cells to cytarabine is increased by suppressing the expression of Heme oxygenase-1 and hypoxia-inducible factor 1-alpha

Abstract Background Acute myeloid leukemia (AML), a malignancy Often resistant to common chemotherapy regimens (Cytarabine (Ara-c) + Daunorubicin (DNR)), is accompanied by frequent relapses. Many factors are involved in causing chemoresistance. Heme Oxygenase-1 (HO-1) and Hypoxia-Inducible Factor 1-...

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Principais autores: Mohammad Sadeghi, Asma Moslehi, Hadiseh Kheiry, Fariba Karoon Kiani, Asieh Zarei, Atefeh Khodakarami, Vahid Karpisheh, Ali Masjedi, Badrossadat Rahnama, Mohammad Hojjat-Farsangi, Mortaza Raeisi, Mehdi Yousefi, Ali Akbar Movasaghpour Akbari, Farhad Jadidi-Niaragh
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-06-01
coleção:Cancer Cell International
Assuntos:
Cancer immunotherapy
AML
HO-1
HIF-1α
Cytarabine
Leukemia
Acesso em linha:https://doi.org/10.1186/s12935-024-03393-3
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