Reprogramming the enduracidin NRPS assembly line via thioesterase domain relocation
The rational engineering of multi-megadalton nonribosomal peptide synthetase (NRPS) assembly lines remains a formidable challenge due to their immense size and complexity. Conventional module deletion often disrupts the native cyclization, limiting the generation of analogues with predictable macroc...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
KeAi Communications Co., Ltd.
2027-01-01
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| Col·lecció: | Synthetic and Systems Biotechnology |
| Matèries: | |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S2405805X26001560 |
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