Anti-HER2/neu TCR-T Cells in Action: linking transcriptional signatures, secretomics, and In Vivo tumor suppression

IntroductionT cell receptor-engineered T cell therapy has emerged as a promising approach in cancer immunotherapy, leveraging the ability of T cells to recognize tumor antigens presented on major histocompatibility complex molecules, offering a targeted approach for treating cancers. This study adva...

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Principais autores:	Saleh Alrhmoun, Roman Perik-Zavodskii, Marina Fisher, Julia Lopatnikova, Olga Perik-Zavodskaia, Julia Shevchenko, Kirill Nazarov, Julia Philippova, Vasily Kurilin, Olga Kichakova, Evgenii Zavjalov, Elena Golikova, Petr Timashev, Petr Glybochko, Sergey Sennikov
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-11-01
Colecção:	Frontiers in Immunology
Assuntos:	TCR-T cells TCR-T T cells adoptive cell therapy her2/neu ErbB2
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1646404/full
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