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Synergistic engineering PETase reveals loop-region mutations for enhanced catalytic activity and thermal stability

Biodegradation of Polyethylene Terephthalate (PET) offer a strategic avenue for addressing the global plastic pollution crisis. However, the degradation performance of PET hydrolases remains a technological bottleneck for the industrial realization of plastic biodegradation. In this study, we employ...

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Main Authors: Yuxin Han, Shilong Xing, Mingzhu Ding, Ying Wang, Wenhai Xiao, Yixun Jiang, Mingdong Yao
Format: Artigo
Language:Inglês
Published: KeAi Communications Co., Ltd. 2026-03-01
Series:Synthetic and Systems Biotechnology
Subjects:
Polyethylene terephthalate
Plastic degradation
IsPETase
Biocatalysis
Directed evolution
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X25001632
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