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Hepatitis C virus controls interferon production through PKR activation.

Hepatitis C virus is a poor inducer of interferon (IFN), although its structured viral RNA can bind the RNA helicase RIG-I, and activate the IFN-induction pathway. Low IFN induction has been attributed to HCV NS3/4A protease-mediated cleavage of the mitochondria-adapter MAVS. Here, we have investiga...

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Principais autores: Noëlla Arnaud, Stéphanie Dabo, Patrick Maillard, Agata Budkowska, Katerina I Kalliampakou, Penelope Mavromara, Dominique Garcin, Jacques Hugon, Anne Gatignol, Daisuke Akazawa, Takaji Wakita, Eliane F Meurs
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2010-05-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC2868028?pdf=render
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