MALT1 Inhibition as a Therapeutic Strategy in T-Cell Acute Lymphoblastic Leukemia by Blocking Notch1-Induced NF-κB Activation

Current treatment of T-cell acute lymphoblastic leukemia (T-ALL) is primarily based on high-intensity combination chemotherapy, which has serious side effects. Therefore, developments of novel targeted therapeutics are urgently needed for treatment of T-ALL. In this study, we found that mucosa-assoc...

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Hauptverfasser:	Rong Wang, Huihui Zhang, Jiawen Xu, Ninghan Zhang, Ting Pan, Xiaomin Zhong, Huanxin Zhang, Lingling Yin, Yao Yao, Qingyun Wu, Zhenyu Li, Xuejiao Liu, Kailin Xu, Mingshan Niu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2020-09-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	T-ALL MALT1 MI-2 Notch1 NF-κB
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fonc.2020.558339/full
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