Post-Translational Modifications Modulate Proteinopathies of TDP-43, FUS and hnRNP-A/B in Amyotrophic Lateral Sclerosis

It has been shown that protein low-sequence complexity domains (LCDs) induce liquid-liquid phase separation (LLPS), which is responsible for the formation of membrane-less organelles including P-granules, stress granules and Cajal bodies. Proteins harbouring LCDs are widely represented among RNA bin...

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Detalhes bibliográficos

Principais autores:	Stefania Farina, Francesca Esposito, Martina Battistoni, Giuseppe Biamonti, Sofia Francia
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-07-01
coleção:	Frontiers in Molecular Biosciences
Assuntos:	post-translational modifications RNA binding proteins low-complexity domain protein aggregations amyotrophic lateral sclerosis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmolb.2021.693325/full
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