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Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen.

When cells swell in hypo-osmotic solutions, chloride-selective ion channels (Cl(swell)) activate to reduce intracellular osmolality and prevent catastrophic cell rupture. Despite intensive efforts to assign a molecular identity to the mammalian Cl(swell) channel, it remains unknown. In an unbiased g...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Stephanie C Stotz, David E Clapham
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science (PLoS) 2012-01-01
Sarja:PLoS ONE
Linkit:http://europepmc.org/articles/PMC3464265?pdf=render
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