BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer subtype often treated with radiotherapy (RT). Due to its intrinsic heterogeneity and lack of effective targets, it is crucial to identify novel molecular targets that would increase RT efficacy. Her...

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Detalhes bibliográficos

Principais autores:	Sushmitha Sriramulu, Shivani Thoidingjam, Wei-Min Chen, Oudai Hassan, Farzan Siddiqui, Stephen L. Brown, Benjamin Movsas, Michael D. Green, Anthony J. Davis, Corey Speers, Eleanor Walker, Shyam Nyati
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-06-01
coleção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	BUB1 DNA damage response Radiation sensitization NHEJ DNAPK TNBC
Acesso em linha:	https://doi.org/10.1186/s13046-024-03086-9
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