Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesis

Abstract Rheumatoid arthritis (RA) is an autoimmune disorder that triggers progressive joint destruction by inducing excessive osteoclastogenesis. Porphyromonas gingivalis (Pg), the main pathogenic bacterium involved in periodontitis (PD), is closely related to RA. Pg can secrete extracellular vesic...

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Autori principali:	Jiajie Guo, Qiujing Qiu, Xiaoyuan Yan, Zeying Zhang, Xiyue Zhang, Na An, Chengcheng Yin, Di Yang, Hirohiko Okamura, Kaya Yoshida, Hongchen Sun, Lihong Qiu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2026-02-01
Serie:	International Journal of Oral Science
Accesso online:	https://doi.org/10.1038/s41368-025-00416-1
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