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miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene

Abstract Background Metastasis is the leading cause of cancer mortality and is a major hurdle for lung cancer treatment. Invadopodia, which are cancer-specific protrusive structures, play a crucial role in the metastatic cascade through degradation of the basement membrane and surrounding stroma. Co...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Yongwen Li, Hongbing Zhang, Hao Gong, Yin Yuan, Ying Li, Cong Wang, Weiting Li, Zihe Zhang, Minghui Liu, Hongyu Liu, Jun Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2018-07-01
Schriftenreihe:Journal of Experimental & Clinical Cancer Research
Schlagworte:
Lung cancer
miRNA-182
Cortactin
Metastasis
Invadopodia
Online-Zugang:http://link.springer.com/article/10.1186/s13046-018-0824-1
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