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Thiazolidinedione an auspicious scaffold as PPAR-γ agonist: its possible mechanism to Manoeuvre against insulin resistant diabetes mellitus

Thiazolidinedione (TZD) plays a crucial role in activating PPAR-γ receptor, which helps to inhibit insulin-resistant diabetes mellitus through binding with DNA by forming a complex with retinoid receptors. TZD derivatives are the sulphur and nitrogen containing heterocyclic compounds that have a mas...

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Principais autores: Sourav Basak, Anjali Murmu, Balaji Wamanrao Matore, Partha Pratim Roy, Jagadish Singh
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2024-08-01
Series:European Journal of Medicinal Chemistry Reports
Assuntos:
Thiazolidinedione
PPAR-γ
Anti-diabetic
Heterocyclic compound
Insulin-resistance
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2772417424000323
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