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Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold

Ion channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and modulation. Recent breakthroughs in deep learning-ba...

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Autori principali: Phuong Tran Nguyen, Brandon John Harris, Diego Lopez Mateos, Adriana Hernández González, Adam Michael Murray, Vladimir Yarov-Yarovoy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2024-12-01
Serie:Channels
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Accesso online:https://www.tandfonline.com/doi/10.1080/19336950.2024.2325032
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