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Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands

The synthesis of seventeen new 1,3-diaryl-5-oxo-proline derivatives as endothelin receptor (ETR) ligands is described. The structural configuration of the new molecules was determined by analyzing selected signals in proton NMR spectra. In vitro binding assays of the human ET<sub>A</sub> and ET<sub>...

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Principais autores: Sebastiano Intagliata, Mohamed A. Helal, Luisa Materia, Valeria Pittalà, Loredana Salerno, Agostino Marrazzo, Alfredo Cagnotto, Mario Salmona, Maria N. Modica, Giuseppe Romeo
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2020-04-01
Series:Molecules
Assuntos:
endothelin receptors
ET<sub>A</sub> ligands
1,3-diaryl-5-oxo-proline derivatives
homology modeling
molecular docking
Acceso en liña:https://www.mdpi.com/1420-3049/25/8/1851
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