Inhibitory Peptide of Soluble Guanylyl Cyclase/Trx1 Interface Blunts the Dual Redox Signaling Functions of the Complex

Soluble guanylyl cyclase (GC1) and oxido-reductase thioredoxin (Trx1) form a complex that mediates two NO signaling pathways as a function of the redox state of cells. Under physiological conditions, reduced Trx1 (rTrx1) supports the canonical NO-GC1-cGMP pathway by protecting GC1 activity from thio...

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Autors principals:	Chuanlong Cui, Ping Shu, Tanaz Sadeghian, Waqas Younis, Hong Li, Annie Beuve
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-04-01
Col·lecció:	Antioxidants
Matèries:	thioredoxin oxidative stress NO transnitrosation mimetic peptide soluble guanylyl cyclase
Accés en línia:	https://www.mdpi.com/2076-3921/12/4/906
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