A Thermodynamic Analysis of the Binding Specificity between Four Human PDZ Domains and Eight Host, Viral and Designed Ligands

PDZ domains are binding modules mostly involved in cell signaling and cell–cell junctions. These domains are able to recognize a wide variety of natural targets and, among the PDZ partners, viruses have been discovered to interact with their host via a PDZ domain. With such an array of relevant and...

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Principais autores:	Eva S. Cobos, Ignacio E. Sánchez, Lucía B. Chemes, Jose C. Martinez, Javier Murciano-Calles
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-07-01
coleção:	Biomolecules
Assuntos:	PDZ domain binding specificity virus thermodynamics isothermal titration calorimetry differential scanning calorimetry
Acesso em linha:	https://www.mdpi.com/2218-273X/11/8/1071
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