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Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer.

Amyloid formation of the human plasma protein transthyretin (TTR) is associated with several human disorders, including familial amyloidotic polyneuropathy (FAP) and senile systemic amyloidosis. Dissociation of TTR's native tetrameric assembly is the rate-limiting step in the conversion into amyloid...

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Autors principals: Irina Iakovleva, Afshan Begum, Kristoffer Brännström, Alexandra Wijsekera, Lina Nilsson, Jin Zhang, Patrik L Andersson, A Elisabeth Sauer-Eriksson, Anders Olofsson
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2016-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC4836675?pdf=render
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