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Glycosaminoglycan-functionalized hydrogels for sustained delivery of tissue inhibitor of metalloproteinase-3 mediating matrix metalloprotease inhibition and extracellular matrix stabilization

Excessive protease activity and impaired tissue regeneration are hallmarks of many disease states. Elevated matrix metalloproteinase-9 (MMP-9) plays a key role in adverse tissue remodeling by excessively degrading extracellular matrix (ECM) components and growth factors. Tissue inhibitor of metallop...

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Principais autores: Fabian Junker, Stefan Rupf, Paula Marie Schindler, Cedric Wilden, Mathias Hohl, Gloria Ruiz-Gómez, M. Teresa Pisabarro, Selina Wrublewsky, Caroline Bickelmann, Charlotte Berhorst, Dalia Alansary, Ben Wieland, Markus Bischoff, Poh Soo Lee, Stephanie Moeller, Albrecht Berg, Tobias A. Dancker, Marcel A. Lauterbach, Bergita Ganse, Leticia Prates Roma, Therese Steudter, Wolfgang Metzger, Thomas Tschernig, Emmanuel Ampofo, Matthias W. Laschke, Matthias Hannig, Sandra Rother
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2026-07-01
Serier:Bioactive Materials
Fag:
Tissue inhibitor of metalloproteinase-3 (TIMP-3)
Matrix degradation
Glycosaminoglycans (GAGs)
Matrix metalloprotease-9 (MMP-9)
Hydrogel
Online adgang:http://www.sciencedirect.com/science/article/pii/S2452199X2600071X
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