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Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens

Summary: Host cell cytosol is monitored by inflammasomes. Cytosolic invasion of pathogens involves breaching endolysosomal membranes, which is sensed by galectins triggering endolysosomal damage response. Whether and how endomembrane damage surveillance impacts inflammasome sensing of pathogens is u...

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Principais autores: Sonia Shivcharan, Doulathunnisa Ahamed Younis, Skylar S. Wright, Chengliang Wang, Bharat Behl, Patience Shumba, Kristina N. Delgado, Arshmeet K. Chawla, Neal M. Alto, Noorjahan Panjwani, Sivapriya Kailasan Vanaja, Jianbin Ruan, Zhichao Fan, Vijay A. Rathinam
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-08-01
Serier:Cell Reports
Fag:
CP: Immunology
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124725007739
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