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Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis

Abstract Red blood cell development from erythroid progenitors requires profound reshaping of metabolism and gene expression. How these transcriptional and metabolic alterations are coupled is unclear. Nprl3 (an inhibitor of mTORC1) has remained in synteny with the α-globin genes for >500 million ye...

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Principais autores: Alexandra E. Preston, Joe N. Frost, Megan R. Teh, Mohsin Badat, Andrew E. Armitage, Ruggiero Norfo, Sarah K. Wideman, Muhammad Hanifi, Natasha White, Noémi BA. Roy, Christian Babbs, Bart Ghesquiere, James Davies, Andrew JM. Howden, Linda V. Sinclair, Jim R. Hughes, Mira Kassouf, Rob Beagrie, Douglas R. Higgs, Hal Drakesmith
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2025-03-01
Series:Nature Communications
Acceso en liña:https://doi.org/10.1038/s41467-025-57683-z
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