The effect of the potential PhoQ histidine kinase inhibitors on Shigella flexneri virulence.

PhoQ/PhoP is an important two-component system that regulates Shigella virulence. We explored whether the PhoQ/PhoP system is a promising target for new antibiotics against S. flexneri infection. By using a high-throughput screen and enzymatic activity coupled assay, four compounds were found as pot...

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Principais autores:	Xia Cai, Jian Zhang, Mingliang Chen, Yang Wu, Xueqing Wang, Jiayu Chen, Junqin Zhang, Xu Shen, Di Qu, Hualiang Jiang
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Public Library of Science (PLoS) 2011-01-01
סדרה:	PLoS ONE
גישה מקוונת:	http://europepmc.org/articles/PMC3154276?pdf=render
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