Bioengineering of Cytochrome P450 OleT_JE: How Does Substrate Positioning Affect the Product Distributions?

The cytochromes P450 are versatile enzymes found in all forms of life. Most P450s use dioxygen on a heme center to activate substrates, but one class of P450s utilizes hydrogen peroxide instead. Within the class of P450 peroxygenases, the P450 OleT_JE isozyme binds fatty acid substrates an...

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Hlavní autoři:	Fabián G. Cantú Reinhard, Yen-Ting Lin, Agnieszka Stańczak, Sam P. de Visser
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-06-01
Edice:	Molecules
Témata:	density functional theory enzyme catalysis enzyme mechanism QM/MM methods heme enzymes bioengineering
On-line přístup:	https://www.mdpi.com/1420-3049/25/11/2675
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