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Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21.

Trisomy of chromosome 21, the genetic cause of Down syndrome, has the potential to alter expression of genes on chromosome 21, as well as other locations throughout the genome. These transcriptome changes are likely to underlie the Down syndrome clinical phenotypes. We have employed RNA-seq to under...

Повний опис

Збережено в:
Бібліографічні деталі
Автори: Patrick K Gonzales, Christine M Roberts, Virginia Fonte, Connor Jacobsen, Gretchen H Stein, Christopher D Link
Формат: Artigo
Мова:Inglês
Опубліковано: Public Library of Science (PLoS) 2018-01-01
Серія:PLoS ONE
Онлайн доступ:http://europepmc.org/articles/PMC5870938?pdf=render
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