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Activation of primary hepatic stellate cells and liver fibrosis induced by targeting TGF-β1/Smad signaling in schistosomiasis in mice

Abstract Background In mice, liver fibrosis is the most serious pathologic change during Schistosoma japonicum (S. japonicum) infection. Schistosomiasis is mainly characterized by schistosome egg-induced granulomatous fibrosis. Hepatic stellate cells (HSCs) are mainly responsible for the net accumul...

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Principais autores: Ping Huang, Huihui Ma, Yun Cao, Tingzheng Zhan, Tingting Zhang, Xinyi Wang, Yanan Zhang, Jing Xu, Chaoming Xia
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-12-01
Serier:Parasites & Vectors
Fag:
Schistosomiasis
Liver fibrosis
Hepatic stellate cells
TGF-β1/Smad signaling
MicroRNAs
Online adgang:https://doi.org/10.1186/s13071-022-05584-1
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