The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau

Tau35 is a truncated form of tau found in human brain in a subset of tauopathies. Tau35 expression in mice recapitulates key features of human disease, including progressive increase in tau phosphorylation, along with cognitive and motor dysfunction. The appearance of aggregated tau suggests that Ta...

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Principais autores:	Chen Lyu, Stefano Da Vela, Youssra Al-Hilaly, Karen E. Marshall, Richard Thorogate, Dmitri Svergun, Louise C. Serpell, Annalisa Pastore, Diane P. Hanger
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2021-10-01
Serija:	Frontiers in Molecular Biosciences
Teme:	biophysical studies hybrid methods tauopathy tau truncation small angle x-ray scattering intrinsically disordered proteins
Online dostop:	https://www.frontiersin.org/articles/10.3389/fmolb.2021.779240/full
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