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Identification of the Hepatic Metabolites of Flumazenil and their Kinetic Application in Neuroimaging

Studies of the neurobiological causes of anxiety disorders have suggested that the γ-aminobutyric acid (GABA) system increases synaptic concentrations and enhances the affinity of GABA<sub>A</sub> (type A) receptors for benzodiazepine ligands. Flumazenil antagonizes the benzodiazepine-binding site o...

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Principais autores: Wei-Hsi Chen, Chuang-Hsin Chiu, Shiou-Shiow Farn, Kai-Hung Cheng, Yuan-Ruei Huang, Shih-Ying Lee, Yao-Ching Fang, Yu-Hua Lin, Kang-Wei Chang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-05-01
coleção:Pharmaceuticals
Assuntos:
flumazenil
LC-QqQ MS
metabolism
γ-aminobutyric acid receptor antagonist
benzodiazepine receptors
Acesso em linha:https://www.mdpi.com/1424-8247/16/5/764
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