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Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells

Myeloid-derived suppressor cells (MDSCs) are a hetero geneous group of cells, which can suppress the immune response, promote tumor progression and impair the efficacy of immunotherapies. Consequently, the pharmacological targeting of MDSC is emerging as a new immunotherapeutic strategy to stimulate...

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Uloženo v:
Hlavní autoři: Wei Huang, Yaping Liu, Anthony Luz, Mark Berrong, Joel N. Meyer, Yujing Zou, Excel Swann, Pasupathi Sundaramoorthy, Yubin Kang, Shekeab Jauhari, William Lento, Nelson Chao, Luigi Racioppi
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021-10-01
Edice:Frontiers in Immunology
Témata:
tumor microenvionment
MDSC (myeloid-derived suppressor cell)
anti-tumor immune response
CaMKK β
AMPK
ROS - reactive oxygen species
On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2021.754083/full
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