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Changing topographic Hox expression in blood vessels results in regionally distinct vessel wall remodeling

Summary The distinct topographic Hox expression patterns observed in vascular smooth muscle cells (VSMCs) of the adult cardiovascular system suggest that these transcriptional regulators are critical for maintaining region-specific physiological properties of blood vessels. To test this proposition,...

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Main Authors: Nathanael D. Pruett, Zoltan Hajdu, Jing Zhang, Richard P. Visconti, Michael J. Kern, Deneen M. Wellik, Mark W. Majesky, Alexander Awgulewitsch
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2012-03-01
Series:Biology Open
Subjects:
Hox
Smooth muscle cells
Vascular
Positional identity
Vascular remodeling
Topographic gene expression
Online Access:http://bio.biologists.org/content/1/5/430
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