Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning

Abstract The fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence determinants at the fusion peptide and its adjacent regions for pathogenicity and antigenicity remain elusive. In...

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Bibliografische Detailangaben

Hauptverfasser:	Ruipeng Lei, Enya Qing, Abby Odle, Meng Yuan, Chaminda D. Gunawardene, Timothy J. C. Tan, Natalie So, Wenhao O. Ouyang, Ian A. Wilson, Tom Gallagher, Stanley Perlman, Nicholas C. Wu, Lok-Yin Roy Wong
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-05-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-024-48104-8
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