Population pharmacokinetics of colistin sulfate in critically ill patients based on NONMEM

Abstract As the last defense against multidrug-resistant gram-negative bacteria, colistin sulfate’s clinical use, which is often empirical, risks resistance and adverse reactions. This study aimed to develop a population pharmacokinetic (PPK) model of colistin sulfate for critically ill patients and...

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Hlavní autoři:	Qiang Sun, Xiaojing Li, Genzhu Wang, Xiaoying Wang, Baiqian Xing, Zhikun Xun, Nianfang Lu, Zhongdong Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-05-01
Edice:	Scientific Reports
Témata:	Colistin sulfate Population pharmacokinetics Therapeutic drug monitoring Dosing regimen Two-compartment models
On-line přístup:	https://doi.org/10.1038/s41598-025-03503-9
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