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Genetically stratified Parkinson’s disease with freezing of gait is related to specific pattern of cognitive impairment and non-motor dominant endophenotype

BackgroundFreezing of gait (FOG) is an important milestone in the individual disease trajectory of people with Parkinson’s disease (PD). Based on the cognitive model of FOG etiology, the mechanism behind FOG implies higher executive dysfunction in PDFOG+. To test this model, we investigated the FOG-...

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Principais autores: Lukas Pavelka, Rajesh Rawal, Stefano Sapienza, Jochen Klucken, Claire Pauly, Venkata Satagopam, Rejko Krüger
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-10-01
coleção:Frontiers in Aging Neuroscience
Assuntos:
Parkinson’s disease
non-motor symptoms
cognitive subdomain
executive dysfunction
visuospatial impairment
endophenotype
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1479572/full
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