An 8-Hydroxy-Quinoline Derivative Protects Against Lipopolysaccharide-Induced Lethality in Endotoxemia by Inhibiting HMGB1-Mediated Caspase-11 Signaling

Sepsis, an inflammatory syndrome secondary to infection, is the leading cause of in-hospital lethality. It is evidenced that LPS, the major pathological component of the Gram-negative bacteria membrane, predominantly contributes to the pathogenesis of sepsis. Cytoplasmic lipopolysaccharide (LPS) can...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Xiangyu Wang, Jian Shi, Zhaozheng Li, Ling Li, Rui Zhang, Yang Bai, Junmei Li, Fang Liang, Yiting Tang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-05-01
coleção:	Frontiers in Pharmacology
Assuntos:	caspase-11 pyroptosis inflammasome phenotypic screening sepsis HMGB1
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2021.673818/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!