A novel DCSTAMP antagonist impedes preosteoclast fusion via modulation of RAP1B–RAC1-mediated cytoskeletal remodeling
Abstract DCSTAMP serves as a critical fusogenic protein orchestrating cell–cell fusion during osteoclastogenesis. The disruption of DCSTAMP functionality preserves preosteoclasts, thereby augmenting bone mass through both anabolic and anti-catabolic mechanisms. Despite its therapeutic potential, spe...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2025-12-01
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| Collection: | Experimental and Molecular Medicine |
| Accès en ligne: | https://doi.org/10.1038/s12276-025-01591-1 |
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