Genetic suppressor of autophagy defects in huntingtin null cells identified using a mutagenesis screen in Dictyostelium discoideum

Abstract Background Huntingtin (HTT) is an important gene for cellular processes such as autophagy, and its loss leads to neurodegenerative disease phenotypes. In Dictyostelium discoideum, HTT-null (htt-) cells exhibit impaired basal autophagy and fail to develop in the presence of ammonium chloride...

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Principais autores:	Lauren Cuoco, Shelbi E. Gill, Luc Francois, Sarah Souders, Caroline DeMasi, Jeffrey R. Moore, Frédéric J. J. Chain
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2026-02-01
Serija:	BMC Molecular and Cell Biology
Teme:	HTT HD Huntington’s disease Cargo degradation Vesicle trafficking Neurodegeneration
Online dostop:	https://doi.org/10.1186/s12860-026-00570-2
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