Sirtuin 1 Inhibiting Thiocyanates (S1th)—A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases

Sirtuin 1 (Sirt1) is a NAD+ dependent lysine deacetylase associated with the pathogenesis of various diseases including cancer. In many cancer types Sirt1 expression is increased and higher levels have been associated with metastasis and poor prognosis. However, it was also shown, that Sirt1 can hav...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Nathalie Wössner, Zayan Alhalabi, Jessica González, Sören Swyter, Jin Gan, Karin Schmidtkunz, Lin Zhang, Alejandro Vaquero, Huib Ovaa, Oliver Einsle, Wolfgang Sippl, Manfred Jung
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2020-04-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	sirtuins lysine deacetylase thiocyanate DNA damage histone H2AX
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fonc.2020.00657/full
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