Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction

Abstract Disruption of bone homeostasis caused by metastatic osteolytic breast cancer cells increases inflammatory osteolysis and decreases bone formation, thereby predisposing patients to pathological fracture and cancer growth. Alteration of osteoblast function induces skeletal diseases due to the...

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Principais autores:	Jungho Back, Minh Nam Nguyen, Lu Li, Saelim Lee, Inkyu Lee, Fancheng Chen, Lauren Gillinov, Yeon-Ho Chung, Kareme D. Alder, Hyuk-Kwon Kwon, Kristin E. Yu, Christopher M. Dussik, Zichen Hao, Michael J. Flores, Yoseph Kim, Izuchukwu K. Ibe, Alana M. Munger, Sung Wook Seo, Francis Y. Lee
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Publishing Group 2021-09-01
Serija:	Bone Research
Online dostop:	https://doi.org/10.1038/s41413-021-00158-w
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