Proton pump inhibitors in critically ill mechanically ventilated patients with COVID-19: protocol for a substudy of the Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial

Abstract Background Critically ill patients commonly receive proton pump inhibitors (PPIs) to prevent gastrointestinal (GI) bleeding from stress-induced ulceration. Despite widespread use in the intensive care unit (ICU), observational data suggest that PPIs may be associated with adverse outcomes i...

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Autori principali:	Brittany B. Dennis, Lehana Thabane, Diane Heels-Ansdell, Joanna C. Dionne, Alexandra Binnie, Jennifer Tsang, Gordon Guyatt, Aijaz Ahmed, François Lauzier, Adam Deane, Yaseen Arabi, John Marshall, Nicole Zytaruk, Lois Saunders, Simon Finfer, John Myburgh, John Muscedere, Shane English, Marlies Ostermann, Miranda Hardie, Serena Knowles, Deborah Cook, For the REVISE Investigators the Canadian Critical Care Trials Group
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-08-01
Serie:	Trials
Soggetti:	Randomization Critically ill COVID-19 pandemic Hospital transfers Stress ulceration Gastrointestinal bleeding
Accesso online:	https://doi.org/10.1186/s13063-023-07589-2
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